This manuscript contains four sermons by John Donne, all of which were written out by Knightly Chetwood (or Chetwode), apparently when he was a young man, no older than around twenty-one. The volume contains further sermons, by Joseph Hall and by 'Dr Scott', as well as other miscellaneous material. Later in the seventeenth-century, it was owned by Katherine Butler (the manuscript was 'Given me by my Father May 1693'), who reversed the manuscript and used it as a commonplace book. Written from the other end are also two letters, one from Dr Tillotson to the Duke of Shrewsbury, and the other from Dr Radcliffe to an unnamed recipient.
The manuscript has been described more fully by Evelyn Simpson, ‘A Donne Manuscript in St Paul’s Cathedral Library’, Philological Quarterly, 21 (1942), pp. 237-9. See also the ODNB entry on the later Knightly Chetwode, Dean of Gloucester: Hugh de Quehen, ‘Chetwood, Knightly (bap. 1650, d. 1720)’, Oxford Dictionary of National Biography, Oxford University Press, 2004; online edn, Jan 2008.